Tkinter is the standard Python GUI framework and comes bundled with Python. It provides a simple and easy-to-use interface for creating GUI applications.
PyQt
PyQt is a set of Python bindings for the Qt framework. It offers a comprehensive set of tools and widgets for building feature-rich GUI applications. PyQt is known for its flexibility and robustness.
Kivy
Kivy is an open-source Python library for developing multitouch applications. It's cross-platform and supports various input methods, making it suitable for both desktop and mobile application development.
wxPython
wxPython is a Python wrapper for wxWidgets, a C++ GUI toolkit. It provides native-looking widgets and supports multiple platforms, including Windows, macOS, and Linux.
PySide
PySide is another set of Python bindings for the Qt framework. It offers a similar feature set to PyQt and is compatible with Qt Designer for visual application design.
PyGTK
PyGTK is a set of Python bindings for the GTK+ toolkit. It allows developers to create applications that blend well with the GNOME desktop environment.
PySimpleGUI
PySimpleGUI is a lightweight and beginner-friendly GUI framework that aims to simplify the process of creating GUIs in Python. It provides a simple API and supports multiple GUI backends, including tkinter, PyQt, and wxPython.
PyGObject
PyGObject is a Python binding for the GObject library, which is the foundation of the GTK+ toolkit. It enables developers to create GTK+ applications using Python.